Population-level effectiveness of a national HIV preexposure prophylaxis programme in MSM
نویسندگان
چکیده
Objective: The aim of this study was to evaluate Scotland's national HIV preexposure prophylaxis (PrEP) programme in relation PrEP uptake and associated population-level impact on incidence among MSM. Design: A retrospective cohort within real-world implementation. Methods: Comparison diagnoses from surveillance data a HIV-negative MSM attending sexual health clinics the National Sexual Health information system between 2-year periods pre(July 2015–June 2017) post(July 2017–June 2019) introduction PrEP. Results: Of 16 723 services period, 3256 (19.5%) were prescribed Between pre-PrEP periods, new declined 229 184, respectively [relative risk reduction (RRR): 19.7%, 95% confidence interval (95% CI) 2.5–33.8]; diagnosed recently acquired infections an estimated 73 47, (35.6%, CI 7.1–55.4). Among clinics, per 1000 person-years 5.13 3.90–6.64) 3.25 2.30–4.47) period (adjusted IRR 0.57, 0.37–0.87). Compared with lower for those (aIRR 0.25, 0.09–0.70) not 0.68, 0.43–1.05). Conclusion: We demonstrate first time setting. reduced who had been and, lesser extent, not. Promotion benefits needs extend do access clinics.
منابع مشابه
Preexposure Prophylaxis for HIV Prevention
This interactive feature addresses the diagnosis or management of a clinical case. A case vignette is followed by specific clinical options, none of which can be considered either correct or incorrect. In short essays, experts in the field then argue for each of the options. In the online version of this feature, available at NEJM.org, readers can participate in forming community opinion by cho...
متن کاملStreamlining HIV testing for HIV preexposure prophylaxis.
HIV-testing algorithms for preexposure prophylaxis (PrEP) should be optimized to minimize the risk of drug resistance, the time off PrEP required to evaluate false-positive screening results, and costs and to expedite the start of therapy for those confirmed to be infected. HIV rapid tests (RTs) for anti-HIV antibodies provide results in less than 1 h and can be conducted by nonlicensed staff a...
متن کاملFirst population-level effectiveness evaluation of a national programme to prevent HIV transmission from mother to child, South Africa
BACKGROUND There is a paucity of data on the national population-level effectiveness of preventing mother-to-child transmission (PMTCT) programmes in high-HIV-prevalence, resource-limited settings. We assessed national PMTCT impact in South Africa (SA), 2010. METHODS A facility-based survey was conducted using a stratified multistage, cluster sampling design. A nationally representative sampl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: AIDS
سال: 2021
ISSN: ['1473-5571', '0269-9370']
DOI: https://doi.org/10.1097/qad.0000000000002790